|5-羟基-10,11-二氢-5H-二苯并[a,d][7]环庚烯|CsnPharm

CAS No.: 1210-34-0

Synonyms: Dibenzo(b,f)cycloheptan-1-ol;10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ol

Dibenzosuberol may show effect of blocking rhinovirus replication in vitro

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400-920-2911

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400-920-2911

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描述A series of derivatives of dibenzofuran and dibenzosuberol block rhinovirus replication in vitro as judged by their ability to hinder the cytopathic effect in cells infected with HRV14 or HRV16. Both the number and the size of viral plaques were reduced effectively by treatment with these compounds in a dose-dependent fashion, thus affecting viral spread. Dibenzosuberenone showed minor differences in selectivity, with IC50 values of 10 and 30 microM for HRV16 and HRV14 cytopathy, respectively. Likewise, dibenzosuberenone effectively prevented the production of HRV16 proteins, viral RNA, and infectious virus particles when present at concentrations above 30 microM. Dibenzosuberenone can block the adsorption of viral particles on to cells, preventing further steps in the replication cycle, but is not effective as a direct inactivating agent^[2].
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CAS号	1210-34-0	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H14O	运输	蓝冰
分子量	210.27	别名	Dibenzo(b,f)cycloheptan-1-ol;10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ol

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